Madonna is making a highly anticipated return to the MTV Video Music Awards (VMAs) stage, and this time she'll be joined by "very special guests." Producer Van Toffler has teased fans about what to expect from the opening performance, hinting at more mayhem than ever before.

Van Toffler, the former MTV president and producer behind Madonna's iconic 2003 three-way kiss at the VMAs, discussed the upcoming show with The Wrap. He shared that Madonna will kick off the 2026 MTV VMAs alongside her mystery collaborators. This marks Madonna's first appearance at the show in 23 years, following her 13-nomination haul for "Confessions II."

The VMAs are returning to Los Angeles for the first time since 2017, and this year's ceremony promises to be just as unforgettable. In fact, Toffler himself seemed excited about creating chaos once again: "I am trying to create the mayhem all over again," he said.

While Toffler didn't reveal too much about the identities or roles of these "very special guests," he did mention that they would include a diverse lineup of artists. Specifically, he stated, "You've got Snoop and Madonna with Yung Lean and Gener8ion and Lisa and Raye and Shaboozey." It remains unclear how these stars will come together, but given their collective talents, it's likely to be an electrifying experience.

Other notable highlights from the 2026 VMAs include Taylor Swift receiving the inaugural MTV VMA Artist Director Honors award, despite uncertainty surrounding her attendance. Additionally, the ceremony will pay tribute to music legends Dolly Parton and George Michael through performances led by Kacey Musgraves, who Toffler praised as "a wonderful embodiment of modern country and strong women in country." Nirvana will also be honored with the Vanguard Award.

The 2026 MTV Video Music Awards will take place live on September 27, marking a long-awaited return to the city where the event last took place in 2017. As Toffler so aptly put it, "for one night, for a couple of hours, they will together, and maybe some mayhem will ensue." what secrets this performance holds – but one thing is certain: the stage is set for a night to remember.